RNA

Main - Science - Biology - Biochemistry_and_Molecular_Biology - Biomolecules - Nucleic_Acids - RNA
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01/09/2009
A never-ending dance of RNA (Nature)
The recreation of life's origins comes a self-catalysing step closer.
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01/08/2009
In Lab, Clues To How Life Began (NPR)
Scientists long to understand how a bunch of chemicals on the early Earth transformed themselves into the first living creatures. Now one lab has made a self-replicating set of RNA molecules that the scientists say may mimic what might have happened during the early evolution of life.
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01/05/2009
A stress-responsive RNA switch regulates VEGFA expression (Nature)
Ligand binding to structural elements in the non-coding regions of messenger RNA modulates gene expression. Ligands such as free metabolites or other small molecules directly bind and induce conformational changes in regulatory RNA elements known as riboswitches. Other types of RNA switches are activated by complexed metabolites|[mdash]|for example, RNA-ligated metabolites such as ...
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01/08/2009
The IN VIVO Blog Selects First Annual 'Deal of the Year' (PR Newswire via Yahoo! Finance)
The readers of The IN VIVO Blog, which provides news, insights and analysis on the biopharmaceutical and medical device industries, have selected a Deal of the Year for 2008 -- Alnylam Pharmaceuticals' RNA interference alliance with Takeda Pharmaceuticals.
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01/08/2009
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis (Nature)
In all organisms, the protein machinery responsible for the replication of DNA, the replisome, is faced with a directionality problem. The antiparallel nature of duplex DNA permits the leading-strand polymerase to advance in a continuous fashion, but forces the lagging-strand polymerase to synthesize in the opposite direction. By extending RNA primers, the lagging-strand polymerase restarts at ...
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01/05/2009
Messenger RNA targeting to endoplasmic reticulum stress signalling sites (Nature)
Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR). ER stress is sensed by Ire1, a transmembrane kinase/endoribonuclease, which initiates the non-conventional splicing of the messenger RNA encoding a key transcription activator, Hac1 in yeast or XBP1 in metazoans. In the absence ...
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01/07/2009
Intradigm Completes Final Part of $21.4 Mln Series B Financing; Names Philip Haworth CEO - Update (Nasdaq)
(RTTNews) - Wednesday, Intradigm Corp., a leading developer of targeted, systemic RNA interference or RNAi therapeutics, announced that it has completed the final part of its Series B financing.
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01/07/2009
Intradigm closes final tranche of $21.4M round, names new CEO (BizJournals)
Intradigm Corp., a developer of targeted, systemic RNA interference therapeutics, said Wednesday it closed the final tranche of its $21.4M second funding round and named a new CEO.
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01/07/2009
Plant Polymerases IV And V Are Special Forms Of Polymerase II (Medical News Today)
It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms of RNA Polymerase II, an essential enzyme of all eukaryotic organisms, including humans.
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01/07/2009
Laboratory Equipment controls sample access and environment. (ThomasNet)
Using external magnetic couplers to drive internal robotics, -20°C Sample Access Manager (SAM) offers temperature-controlled (+20 to -40°C) environment for storing DNA/RNA, compounds, tissue, and protein samples. This piece of laboratory automation equipment also integrates functionality for cherry-picking, sample tracking, and multiple sample type capabilities. Along with software, system ...
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  • Center for RNA Molecular Biology - Lists researchers, graduate programs, employment opportunities and seminars at Case Western Reserve University, Cleveland, Ohio.
  • Lang, Professor B. Franz - Research articles related to mitochondrial RNase P(mtP), secondary structure models of mtP RNA, and links that are subject related.
  • Mamit-tRNA - Gene compilation aimed at defining typical as well as consensus primary and secondary structural features of mammalian mitochondrial tRNAs. Includes a table of organisms, sequences, and 2D structures.
  • Molecular Colony Technique - Studies on RNA recombination applied to quantitative diagnostics, in cell-free gene cloning and screening from The Laboratory of Viral RNA Biochemistry, Pushchino, Russia.
  • Origins of Life and the RNA World - Historical perspective on the role of RNA in the evolution of life.
  • RiboClub - Aims to collaborate for understanding of the roles of RNA and binding proteins in processes like maturation and catalysis. Includes member login and directions to the Faculty of Medecine at University of Sherbrooke, Montreal. [bilingual]
  • Ribosomal Structure - Introduction to ribosomal RNA molecules from E. coli, with references and 3D-model for ribosomal structure in research led by Richard Brimacombe, Berlin, Germany.
  • Ribosome Structure - Projects on 30S, 50S and antibiotic interactions led by François J. Franceschi at the Max-Planck Institute for Molecular Genetics in Hamburg, Germany.
  • RNA - Publishes significant original research in all areas of structure and function in eukaryotic, prokaryotic and viral systems. Articles back to 1997, available by subscription to the RNA Society.
  • The RNA Society - Facilitate sharing and dissemination of experimental results and emerging concepts in ribonucleic acid research. Includes membership data, news and events, meeting calendar, and related links.
  • The RNA Webring - Links together laboratories with an interest in any aspect of RNA function and metabolism. Included is a search engine to help find RNA-related information.
  • The RNA World Website - Provides links to a range of subject areas, including databases, tools, software, books and tutorials, and meetings.
  • RNABase.org - RNA Structure Database: Description of structures, function, origin, experimental techniques. FAQ and latest developments by Venkatesh L. Murthy, Johns Hopkins School of Medicine, Baltimore, MD.
  • RRNDB - Database of over 300 operons, including 77 from whole genome sequence projects, enabling search through the phylogenetic distribution from the Center for Microbial Ecology at MSU, Lansing, MI.
  • Structural Classification of RNA - SCOR database aiming to classify three-dimensional structural motifs and elements, from NMR and X-ray data, according to tertiary interactions and function. Maintained at Berkley, CA.
  • Walter Lab - RNA Biochemistry of catalytic RNA, short ribozymes, folding, FRET, fluorescence, atomic force microscopy. Listing publications back to 1993 from the University of Michigan, Ann Arbor.
  • Wikipedia: Messenger RNA - Article on the RNA that carries information from DNA to protein synthesis.
  • Wikipedia: SECIS element - Article on the sequence that directs translation of UGA as selenocysteine instead of using it as a stop codon.
  • Wikipedia: Transfer RNA - Article on molecules that transport amino acids to their positions on the ribosome during polypeptide synthesis.

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